With regard to Prdm16 expression, we found that KIC and KPC mice behaved similarly to KC mice (Fig. S1, B and C), suggesting that transient expression of Prdm16 might take place even under the presence of the most common and aggressive genetic alterations that facilitate PDAC progression (Hayashi et al., 2021; Iacobuzio-Donahue, 2012). Here, PRDM16 is linked to keratoconus.