Because the MLL gene encodes a histone-3 Lysine-4 (H3K4) methyltransferase that is critical in promoting gene expression during hematopoiesis (Xue et al., 2019), it has been postulated that Prdm16 might suppress leukemia pathogenesis owing to its ability to drive heterochromatin formation (Pinheiro et al., 2012; Zhou et al., 2016). This evidence concerns the gene KMT2A and leukemia.