As concomitant inactivation of Prdm16 appeared to shift the evolution of the IPMN-to-PDAC progression sequence toward the PanIN-to-PDAC progression sequence, it is tempting to speculate that Prdm16 might function at the stage of early preneoplastic lesions to influence PDAC development and progression. The gene discussed is PRDM16; the disease is pancreatic intraductal papillary-mucinous neoplasm.