PRDM16 and pancreatic intraductal papillary-mucinous neoplasm: Collectively, these data demonstrate that concomitant inactivation of Prdm16 was sufficient to confer metastatic properties on non-metastatic KSC tumors, a phenomenon that is associated with a shift from the IPMN-to-PDAC phenotype to the PanIN-to-PDAC phenotype.