VIM and cancer: At the stage of full PDAC, KSPrC tumors were poorly differentiated adenocarcinomas, characterized by loss of the epithelial marker E-cadherin and acquisition of the mesenchymal marker vimentin (Fig. S3 B), which could be due either to increased accumulation of cancer associated fibroblasts or epithelial to mesenchymal transition (EMT), the latter being a general hallmark of metastasis (Pei et al., 2019).