A meta-analysis on the diagnostic accuracy of VEGF for differentiating ATB from TBI showed an overall pooled sensitivity, specificity, NLR, PLR, DOR, and AUC of 0.59, 0.87, 0.47, 4.5, 10.00, and 0.85, respectively, and it had the highest AUC to assist distinction between TBI and active TB, followed by IFN-γ and IL-2 [136]. This evidence concerns the gene IFNG and tuberculosis.