A meta-analysis on the diagnostic accuracy of IL-2 for differentiating active TB from TBI showed an overall pooled sensitivity, specificity, NLR, PLR, DOR, and AUC of 0.83–0.84, 0.66–0.76, 0.22–0.24, 3.41–2.5, 10.00–15.47, and 0.84–0.87, respectively [136,147]. This evidence concerns the gene IL2 and tuberculosis.