TB patients (extrapulmonary TB (EPTB) and PTB) had higher frequencies of ESAT-6/CFP-10–specific IFN-γ CD4 T-cells expressing CD38, HLA-DR, or Ki67 compared with TBI, while EPTB had higher frequencies of cells expressing HLA-DR or Ki67 compared with PTB [188]. This evidence concerns the gene MKI67 and tuberculosis.