The Mtb-specific immune response showed that multiple cytokines, i.e., IFN-γ, IL-2, IL-6, IL-8, IP-10, MCP-1, MIP-1β, and TNF-α, were released when blood from patients with TB (cultured-confirmed) is stimulated with Mtb Ags (ESAT-6+CFP-10+TB7.7) [49]. This evidence concerns the gene IL6 and tuberculosis.