It is also important to mention that the expression of GREB1, CA12, DHRS2, RBBP8, SLC7A5, PLAT, AFF3 and PDGFRL genes were associated with ERα positivity and/or the response to endocrine therapy in breast cancer [30,37,41,43,46,48,97,98]. The gene discussed is AFF3; the disease is breast cancer.