CD8A and neoplasm: FACS analysis showed a decrease of proliferating CD8 T cells in Shp2ΔHK mice 3 weeks after Ras/Myc oncogene injection, relative to Shp2ΔH mice (Figures 12A and 13A), and also a significant reduction of infiltrated CD8 T-cell numbers in tumor areas in Shp2ΔHK mice (Figure 12B).