In previous experiments, we observed that hepatocyte-specific deletion of Src-homology 2 domain-containing tyrosine phosphatase 2 (Shp2) aggravated DEN-induced HCC, similar to the effects of Ikkβ, Jnk1/2, or EGFR removal from hepatocytes. Here, PTPN11 is linked to hepatocellular carcinoma.