We also investigated the effect of Shp2 loss in KCs on tumorigenesis in a primary HCC model after hydrodynamic tail vein injection (HTVi) of 2 oncogenes, N-Rat sarcoma virus (N-Ras) and cellular-Myelocytomatosis (c-Myc), together with a sleeping beauty transposase construct, into WT and Shp2ΔK mice.17 This evidence concerns the gene PTPN11 and hepatocellular carcinoma.