Infection levels of 2522UL and 2450UL organoids with SARS-CoV-2 WA-1 were reduced by 60% upon TSPAN8-blocking antibody treatment (Figures 7K, S7J, and S7K), demonstrating that TSPAN8 plays a functional role in SARS-CoV-2 infection. This evidence concerns the gene TSPAN8 and infection.