SARS-CoV-2-infected patients display neutralizing antibodies that are not to Spike’s ACE2-binding domain (Brouwer et al., 2020; Chi et al., 2020), and these clinical findings together with the unexplained infection variation in 12 different organoids (Figure 4C) motivated us to search for novel host proteins in airway epithelial cells co-opted by SARS-CoV-2. The gene discussed is CHMP5; the disease is infection.