BRCA1 and neoplasm: A key role of the BRCA1/miR-593-5p/MFF axis, with functional implications in mitochondrial fission and cisplatin sensitivity, was also established in vivo in different TCSS-xenografted murine models, where the knockdown of miR-593-5p decreased the negative effect of BRCA1 on mitochondrial apoptosis and fission, whereas the overexpression of this miRNA led to an increase in tumor growth, even in the presence of cisplatin.