In prostate cancer cells, MFF interacts with the voltage-dependent anion channel-1 (VDAC1) at the OMM, and blocking such interaction results in a collapse of mitochondrial functions with increased MOMP, loss of inner membrane potential, Ca2+ unbalance, bioenergetics defects, and activation of cell death pathways [37]. The gene discussed is VDAC1; the disease is prostate cancer.