Mechanistically, it was demonstrated that LL22NC03-N14H11.1 increased phosphorylated ERK1/2, a key positive regulator of Drp1 activation via phosphorylation at S616, and also inhibited the ubiquitination of H-RAS (G12V) mediated by LZTR1, a tumor-suppressor known to repress the MAPK pathway. This evidence concerns the gene DNM1L and neoplasm.