HRAS and hepatocellular carcinoma: Accordingly, the knockdown of LZTR1, or overexpression of H-RAS, restored the proliferation of LL22NC03-N14H11.1-silenced HCC cells as well as the attenuated mitochondrial fission, suggesting that LL22NC03-N14H11.1 exacerbates the malignant phenotype of HCC cells through the targeting of the LZTR1/H-RAS/MAPK pathway [77].