Estrogen receptor positive (ER+) breast cancer cell lines were utilized to knock out linc-ROR expression through CRISPR/Cas9 technology, revealing that linc-ROR functions as an onco-lncRNA to promote growth through activation of the MAPK/ERK pathway by regulating ERK-specific phosphatase DUSP7 [89]. Here, LINC-ROR is linked to breast cancer.