PKM and neoplasm: Conversely, the linc-ROR expression in glioblastoma tumor cells was significantly lower than in normal glial cells, acting as a tumor-suppressor lncRNA by inhibiting the expression of a key component to mTORC2 named Rictor, which in turn suppressed the AKT pathway activity and impaired the expression of glycolytic effectors including Glut1, HK2, PKM2, and LDHA [168].