Another study silenced linc-ROR, which inhibited breast cancer progression via repression of transmethylase MILL1 and TIMP3 [97], while Wnt/β-catenin pathway was blocked through linc-ROR downregulation in MDA-MB-231 breast cancer cells, decreasing colony and sphere numbers along with viability, migration, and invasion inhibition of breast cancer stem cells [102]. This evidence concerns the gene TIMP3 and breast carcinoma.