Finally, the independent influencing factors for long LOS for AHF patients in the ICU were selected by multivariate regression analysis, including respiratory failure (OR 1.672, 95%CI 1.289–2.169, P<0.001), WBC (OR 1.046, 95%CI 1.031–1.061, P<0.001), creatinine (OR 1.221, 95%CI 1.098–1.257, P<0.001), glucose (OR 1.010, 95%CI 1.007–1.012, P<0.001), lactic acid (OR 1.269, 95%CI 1.167–1.381, P<0.001), and albumin (OR 0.559, 95%CI 0.450–0.695, P<0.001) (Table 4). The gene discussed is ALB; the disease is respiratory failure.