CFB and infection: We were able to collect a six-month follow-up sample from nine of the participants who were infected with one of the Omicron variants prior to Feb 2022 (Fig 6G–6J) As expected neutralization titers dropped significantly for the Delta (Fig 6G), BA.1 (Fig 6H) and BA.2.75 (Fig 6I) variants but not for BA.2 (Fig 6J) as few of the participants showed an increase in titers for BA.2 most likely due to natural infection with BA.2 or one of the BA.2 sub-lineages during this period.