To do this, we isolated RNA from cells that had been exposed to: (i) SARS-CoV-2 (“infection”); (ii) trypsin digestion (“digestion”) vs. physical dissociation, (iii) fixation with methanol-acetone (“M-A”) vs. methanol alone (“M”), and (iv) isolation of RNA in the absence or presence of an RNAse 1 inhibitor (“RNAse 1 inhibitor”), as illustrated in Fig 2. Here, RNASE1 is linked to infection.