CRP and dementia: A third strength is that our subjects were primarily African American, a population that is disproportionately impacted by dementia but less studied [68] Lastly, we measured potential mediating biomarkers including CRP, oxidative stress markers, an indirect measure of bacterial endotoxin translocation, and a gene associated with microbial capacity to produce butyrate to allow for a deeper understanding of how the gut microbiome may be related to cognition.