In animal models, the HF diet increased the expression of the proinflammatory cytokines in intestinal tissues, including tumor necrosis factor (TNF)-α, IL-1β, IL-22, and IL-6, as well as the circulating cytokines [29,30], while high fiber diet (inulin and oligofructose) increased IL-10 in Peyer’s patches and concentration of sIgA in cecum [31]. This evidence concerns the gene TNF and hydrops fetalis.