FN1 and neoplasm: Previous studies developed by Hakomori’s group showed that the Tn antigen carried by the glycoprotein acts as a minimal saccharide epitope to generate onf-FN [178,182], which in addition to being highly expressed by tumor cells and modulating the epithelial–mesenchymal transition (EMT) process [157,183,184,185,186], has also recently been detected in alternatively activated human macrophages [187], which display similar phenotypes of tumor-associated macrophages (TAMs) [188,189].