β1,6-GlcNAc–branched N-glycans and MGAT5 also present an essential role in regulation of the immune system, since it has been widely reported that mice deficient in MGAT5, and therefore β1,6-GlcNAc–branched N-glycans, are highly susceptible to autoimmune diseases [34,35]. This evidence concerns the gene MGAT5 and autoimmune disease.