was incorporated into a nano transdermal patch as a bioactive anti-cancer agent against metastatic breast cancer cells, as it interferes with the Bcl-2, Bcl-xL, Bcl-w, and Bad pathways involved in cancer cells’ transformation and malignancy, as well as its chemoprotective effect exemplified by the ability of fucoidan at lower doses to selectively produce apoptosis to cancer cells without causing any toxicity to normal cells in vitro [78]. Here, BCL2L1 is linked to cancer.