Incidentally, the mycotoxin fumagillin, first isolated from Aspergillus fumigatus and originally studied also as an antiangiogenic agent and human MetAP2 inhibitor [154], has been widely used for more than 60 years in apiculture to control nosema disease in honey bees effectively [155] because the microsporidian Nosema apis lacks MetAP1 and targeting MetAP2 suppresses infection. This evidence concerns the gene METAP2 and infection.