GSDMD and lung cancer: In nonsmall cell lung cancer, WNT/β-catenin signaling was proved to promote progression by pyroptosis-related lncRNA FOXD2-AS1,[32] while in colorectal cancer, FOXD2-AS1 may facilitate the progression through the regulation of the EMT signaling pathway.[33] Suppression of oxidative stress can increase NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through the NF-κB-GSDMD pathway.[34] In bladder cancer, the pyroptosis-related lncRNAs might manage the proliferation and progression through the regulation of oxidative stress, EMT, cell adhesion, TGF-β, and WNT signaling pathway.