AKR1B10 and inflammatory bowel disease: Besides, part of studies has proved that AKR1B10 is down-regulated in gastrointestinal cancer and several inflammatory bowel diseases, indicating that its low expression is associated with a bad prognosis and reduced survival rates in colorectal cancer and GC patients.[6,7] The steroid hormone metabolism, bile acid biosynthesis, and the metabolism and production of neurosteroids are all crucial processes in which AKR1C1-4 and AKR1D1 participate.