It was anticipated that GC patients with higher AKR1A1, AKR7A2, and AKR1C3 mRNA levels would have better OS, FP, and PPS as well as a better prognosis (see Fig. S2, http://links.lww.com/MD/I519, Supplemental Content, which illustrates the Relationship between genes and prognosis). This evidence concerns the gene AKR1C3 and gastric cancer.