AKR1B1 and lung cancer: According to Hojnik et al, AKR1B1 is a potential predictive biomarker of serous ovarian cancer and is involved in its pathogenesis.[5]AKR1B10 is overexpressed in human liver cancer, breast cancer, pancreatic cancer, cervical cancer, and smoking-induced lung cancer, and has been identified as a biomarker for nonsmall cell lung cancer (NSCLC).