The results showed that the expression or gene copy number status of AKR1B10, AKR1C1, AKR1C2, AKR6A5, and AKR7A3 in STAD were significantly correlated with the level of immune infiltration of various immune cells, including B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells (DCs), in the tumor microenvironment (Fig. 7A and B). The gene discussed is CD4; the disease is gastric adenocarcinoma.