TP53 and granular cell cancer: As a result, the tumor should be removed with a sufficient margin, including the normal tissues surrounding it.[4] Although there are no histological diagnostic criteria for malignant granular cell tumors, polymorphism, enhanced mitosis, necrosis, and nuclear/cytoplasm rates are the most important features, which are linked to high levels of p53 and Ki67.[8] However, some cases of metastasis are found to have benign microscopic results.