IL1B and delirium: Several studies have shown that intraperitoneal or lateral injection of LPS can induce the infiltration of inflammatory factors into the brain, resulting in delirium-like behavioral changes in mice.[32–35] In cell experiments, exogenous administration of LPS caused microglia to secrete a large number of inflammatory factors, such as IL-1β.[36] Thus, IL-1β may play a key role in cognitive dysfunction.