The most cited keywords were KRAS, BRAF, estimated glomerular filtration rate, colon carcinoma, angiogenesis, microsatellite instability, microRNA, beta-catenin, epithelial-mesenchymal transition (EMT), rectal carcinoma, risk factors, rectum, epidemiology, colorectal carcinoma, meta-analysis, methylation, colon, and P53. The gene discussed is BRAF; the disease is rectal carcinoma.