Analysis of the trend topics revealed that the following keywords were studied in recent years: proliferation, biomarker, migration, EMT, overall survival, autophagy, neoadjuvant chemoradiotherapy, locally advanced rectal cancer, biomarkers, robotic surgery, anastomotic leakage, chemoradiotherapy, metastatic colorectal cancer, KRAS, BRAF, invasion, methylation, meta-analysis, colorectal surgery, laparoscopic surgery, and neoadjuvant therapy. The gene discussed is KRAS; the disease is rectal cancer.