NFKB1 and diffuse large B-cell lymphoma: Various DLBCL subtypes have been shown to have different prognostic implications, including germinal center B cell like and non-GCB.[22] The resistance of non-GCB DLBCL to chemotherapy and the resultant poor prognosis is thought to be due to the constitutive activation of NF-κB and its antiapoptotic target genes.[23,24]