And, among 55 differentially expressed mRNA in circRNA/lncRNA–miRNA–mRNA network, CPEB3, EFNB3, FATA4, growth hormone receptor, GSTZ1, KLF8, MFAP4, PAIP2B, PHACTR3, PITPNM3, RPS6KA6, RSPO3, SLITRK6, SMOC1, STEAP4, SYT1, TMEM132E, TSPAN11, and ZFPM2 were intimately related to the prognosis of HCC patients in Kaplan–Meier plotter analysis (P < .05). This evidence concerns the gene ZFPM2 and hepatocellular carcinoma.