Among 55 mRNA, CPEB3, EFNB3, FATA4, GHR, GSTZ1, KLF8, MFAP4, PAIP2B, PHACTR3, PITPNM3, RPS6KA6, RSPO3, SLITRK6, SMOC1, STEAP4, SYT1, TMEM132E, TSPAN11, and ZFPM2 were intimately bound up with OS in HCC patients. The gene discussed is CPEB3; the disease is hepatocellular carcinoma.