Generous studies have proved that CPEB3 was essential for the development of HCC.[18] Besides, miR-18a-5p, miR-9-5p, miR-20b-5p, miR-224, miR-452-3p, and miR-107 promoted HCC cell proliferation, migration, and invasion by targeting CPEB3.[19–25] In colorectal cancer, CPEB3 knockout in CRC cells enhances CD163 + TAM polarization and M2-like TAM-derived cytokine secretion. This evidence concerns the gene CD163 and colorectal cancer.