IL18 and familial Mediterranean fever: Studies related to Inflammatory bowel diseases indicated that MEFV, which was crucial for inflammasome activation and IL-18 release, thereby reducing inflammation and tumorigenesis.[33] The pyrin protein encoded by the MEFV gene regulates caspase-1 activation and consequently IL-1β maturation in familial Mediterranean fever.[34] TXN and TXNIP belong to the thioredoxin system, which maintains the redox state of cells.