Luteoloside inhibited the proliferation, invasion and metastasis of HCC cells by suppressing the NLRP3 inflammasome.[12,13] Conversely, moderate inflammation, and apoptosis and pyroptosis promoted by inflammasomes can slow cancer progression.[14] For instance, IL-18 production activates the natural killer (NK) cells that exert cytotoxic effects on tumor cells. The gene discussed is NLRP3; the disease is hepatocellular carcinoma.