CASP8 and cancer: Previous studies have shown that HSP90AB1 is overexpressed in various tumors, promotes cancer development and progression by stabilizing the reprogramming of oncogenic proteins.[26] Furthermore, HSP90AB1 can induce endothelial cell-dependent tumor angiogenesis by transcriptionally activating vascular endothelial growth factor receptors (VEGFRs) in HCC cells.[27] CASP7 and CASP8 are key players in the apoptosis cascade.