Sound et al found that inhibition of apoptosis due to inactivating CASP7 mutations is involved in the pathogenesis of various solid tumors in humans.[28] CASP8 is also an established oncogene in some tumors,[29] silencing CASP8 in murine models inhibited the progression of early HCC tumors.[30] Thus, CASP7 and CASP8 are promising diagnostic markers for HCC. The gene discussed is CASP8; the disease is hepatocellular carcinoma.