A retrospective study suggested that high expression of NLRC4 in the normal liver parenchyma surrounding tumor tissues was significantly correlated with worse prognosis of HCC patients.[31] NLRC4-driven IL-1β secretion mediates production of vascular endothelial growth factor-A and tumor cell proliferation during fatty liver disease-induced metastasis.[32] MEFV is a sensor protein that initiates assembly of the inflammasome complex. This evidence concerns the gene IL1B and hepatocellular carcinoma.