TXNIP, a negative regulator of thioredoxin, is downregulated in various aggressive cancers, and has been identified as a tumor suppressor gene.[37–39] Furthermore, TXNIP overexpression in HCC cells induced apoptosis and inhibited proliferation.[40] These genes have been identified as prognostic markers of HCC for the first time in this study. The gene discussed is TXNIP; the disease is hepatocellular carcinoma.