FN1 and cystic fibrosis: Based on gene ontology (GO) analysis, we found that in CF cells, several cellular pathways enriched from 520 downregulated proteins (Log2FC < −0.5) were suppressed, including multiple collagen-related proteins being significantly reduced in CPX-treated CFs, such as three major fibrillar collagens COL1A1, COL1A2, COL3A1, profibrotic receptors PDGFRA and PDGFRB, and fibronectin (FN1) (Figure 6A, Supplementary Table S1).