ETS1 and Jacobsen syndrome: For example, the frog model has been used in the investigation of the role of Nkx2.5 and GATA4 in atrial septal defects [40,41,42], Tbx1 in DiGeorge syndrome [23,43], Tbx5 in Holt-Oram syndrome [44,45,46], Zic3 and Notch in heterotaxy [47,48,49,50,51,52,53], Chd7 in CHARGE syndrome [54,55], and Ets1 in Jacobsen syndrome [56].