In the present study, we observed lower initial PSA levels during the pandemic period (7.7 ng/dL vs. 10.1 ng/dL) and also a shorter time between the biopsy (diagnosis) and first consultation (114 days vs. 69.5 days), possibly as a reflection of PCa screening that has been improving over the years, in spite of the COVID-19 outbreak. Here, KLK3 is linked to COVID-19.