Incubation of peripheral blood lymphocytes with select cytokines such as interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as anti-CD3 antibody induces a CD3+CD56+ subset of lymphocytes with mixed T-cell and NK cell activity (cytokine-induced killer or CIK cells) that possess potent antitumor cytotoxic activity for tumor cells expressing and lacking MHC [12]. Here, HLA-C is linked to neoplasm.