Downstream intracellular signaling of SLAMF7 occurs via phosphorylation of SLAMF7 by Ewing’s sarcoma’s/FLI1-activated transcript 2 (EAT-2) with second messengers phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) accomplishing intracellular amplification of downstream targets resulting in granule release [47,49,50,51]. This evidence concerns the gene SLAMF7 and sarcoma.