A multi-institutional retrospective analysis demonstrated that a Karnofsky Performance Status (KPS) score of 90–100, no extracranial metastases, and epidermal growth factor (EGFR) or anaplastic large-cell lymphoma kinase (ALK) positivity predicted better prognosis in 2186 patients with lung cancer and newly diagnosed BMs [8]. This evidence concerns the gene ALK and lung cancer.