To overcome 5-fluorouracil (5-FU)-induced chemoresistant TNBC, the Ji et al. study [101] demonstrated that the codelivery of LSD1 inhibitor and 5-FU exhibited syngeneic effects in modulating the plasticity of TNBC T-ICs—including reduced Ki67 proliferation, suppressed tumor growth/volume/metastasis and increased CD8+ T cell infiltration. The gene discussed is CD8A; the disease is neoplasm.