PRODH and cancer: It has been reported that regulation of AMP-activated protein kinase (AMPK)plays an important role inthe overexpressionof proline oxidase (POX),responsible for the conversion of proline into pyrroline-5-carboxylate (P5C), which in turn isinvolved in cell survival, apoptotic cell death, and autophagy in cancer cells [67,68,69,70].