We suspect that pathways responsible for cancer development for TSPAN8, UGT2B7, SULT1B1, L1CAM and MYH2 differ according to hormonal status as they vary in females under 55 years of age (pre- and perimenopausal women) and postmenopausal women, whereas, for postmenopausal women, regulation of TSPAN8, UGT2B7 and SULT1B1 could possibly imply that non-sex-hormone mechanisms are involved since their expression is similar to that in males. This evidence concerns the gene TSPAN8 and cancer.