Indeed, increased expression of TSPAN8 has been associated with increased proliferation, migration and angiogenesis induction [25], further supporting the protective role of oestrogen in premenopausal women, whereas UGT2B7 is involved in oestrogen metabolism regulation, with a protective role from genotoxic oxidative products, which could alter the risk of developing cancer [26]. Here, TSPAN8 is linked to cancer.