We recently reported that the non-structural glycoprotein 1 (NS1, 352 amino-acid residues) from epidemic DENV-2 strain RUN-18 isolated from human infection in La Reunion in 2018 was weakly expressed in human hepatoma Huh7 cells in comparison to the NS1 glycoprotein from epidemic DENV-2 strain DES-14 isolated from human infection in Tanzania in 2014 [8]. The gene discussed is ART4; the disease is infection.