AKT1 and myocardial infarction: By contrast, Li et al. reported that hesperidin treatment significantly decreased the myocardial infarct size, myocardial damage, and serum levels of creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) by downregulating p-mTOR, p-Akt, and p-PI3K in vitro [49].