In addition, higher expression of CXCL12 leads to the increased adhesion of prostate cancer cells in the endothelial cell monolayer and immobilized fibronectin, laminin, collagen [154], and osteosarcoma cells [58] due to the upregulation of α5 and β3 integrins. The gene discussed is CXCL12; the disease is Familial prostate cancer.