Our investigation of the anticancer properties of Ficus deltoidea plant extracts and three other varieties of the plants on human prostate cancer cell lines afforded two fractions able to overcome the three main hallmarks of cancer in PC3 cells: apoptosis by activating the intrinsic pathway, inhibition of both migration and invasion by modulating the CXCL12-CXCR4 axis, and inhibiting angiogenesis by modulating VEGF-A expression. Here, CXCL12 is linked to prostate carcinoma.