In activated B cells, the ribosomal protein S4, Y-Linked 1 (RPS4Y1), described as being involved, together with HLA-DQA1, in a resistance to the treatment with corticosteroids combined with cyclosporin A, commonly used in autoimmune diseases, auto-inflammatory diseases, and transplant rejection [14], was significantly downregulated. Here, RPS4Y1 is linked to autoimmune disease.