In particular, it has been found to dampen toll-like receptor (TLR) responses during lipopolysaccharide (LPS) stimulation, but also to poise excessive inflammation during sepsis, hypothetically through cAMP-dependent signaling; furthermore CGRP signaling might influence maturation of CD4+- Cd25+-FOXP3+ lymphocytes [231,232]. Here, CD4 is linked to Sepsis.