Another potential implication for the amylin family of neuropeptides in MS pathogenesis is supported by the observation that AMY, AM, CGRP and Aβ share common catabolic pathways, represented by endopeptidases such as neprilysin (NEP) [252,253,254,255], endothelin converting enzyme [256] and insulin-degrading enzyme [257,258], which have been described as key players in regulating inflammation and degenerative changes within the CNS [259]. The gene discussed is IDE; the disease is myeloid sarcoma.