MADCAM1 and gastroenteritis: Several members of the immunoglobulin superfamily, such as intercellular adhesion molecule-1 (ICAM-1) or CD54, vascular cell adhesion molecule-1 (VCAM-1) or CD106, and mucosal addressin cell adhesion molecule-1 (MAdCAM-1), have established pathogenetic roles in intestinal inflammation, acting as mediators of the aberrant trafficking of leukocytic cells to the inflamed mucosal sites [54].