MAPT and Alzheimer disease: Abnormal β-amyloid (Aβ) accumulation, neurofibrillary tangles associated with Tau protein hyperphosphorylation, oxidative injury, inflammation, apoptosis, dysfunction of autophagy and mitophagy, cholinergic neurons hypofunction, synapses loss, and loss of dendritic spines in the brain are features of pathological alterations of AD [5,6,8,36,37,38].