TNF and polycystic ovary syndrome: One factor in the background of these disorders is the activation of redox-sensitive transcription factors, such as p53 or NF-κB through the activation of different proinflammatory cytokines, such as interleukin-6 (IL-6), IL-18, or tumor necrosis factor (TNF-alfa), described in polycystic ovary syndrome (PCOS) [60].