Further, RASSF1C up-regulation of P4HA2 and PLOD2 expression was confirmed in vivo in lung cancer tissue developed in an orthotopic mouse model (Figure 7) and in breast subcutaneous tumor tissue (Figure 8) derived from breast cancer cells overexpressing RASSF1C or RASSF1A [13]. Here, RASSF1 is linked to neoplasm.