In previously published work we reported that RASSF1C up-regulates PIWIL1 and down-regulates piR-35127 and piR-46545 gene expression in lung cancer cells and restoring expression of these two specific piRNAs in breast and lung cancer cells decreased lung cancer cell and primary epithelial cell proliferation and colony formation [16]. The gene discussed is PIWIL1; the disease is lung cancer.