P4HA2 and PLOD2 are regulated by FOXA1, tumor growth factor-β (TGF-β), and hypoxia-inducible factor-α (HIF-1 α) to induce remodeling of extracellular matrix (ECM) and cancer cell stemness to drive tumor cell invasion and metastasis [26,27,28,29]. This evidence concerns the gene SETD2 and cancer.