Second, HLF and HuH6 cell lines were established from HCC with mutations in the TP53 gene and telomerase reverse transcriptase gene promoter of a 68-year-old male patient and hepatoblastoma with mutations in the TP53 and β-catenin genes of a 1-year-old male patient, respectively [27,28]; thus, the pathological and pathogenic differences, and sex bias must be taken into consideration. This evidence concerns the gene TP53 and hepatocellular carcinoma.