CASP3 and colonic neoplasm: These findings are in agreement with Raju [24] and Thirunavukkarasu [25], who found that diosgenin, a steroidal saponin in the fenugreek plant, displayed anti-proliferative properties by blocking the proliferation of human colon cancer cells (HT-29) and induced apoptosis by exhibiting the activation of caspase-3 and inhibition of Bcl-2.