The present study investigates the anticancer (in vitro) potentials of OME against different colon cancer cells and the chemopreventive (in vivo) efficacy of OME in rats injected with AOM inducers of colon cancer by estimating the incidence of ACF and the evaluation of Bax/Bcl-2 protein expression. Here, BCL2 is linked to malignant colon neoplasm.