We assessed the gene expression of proinflammatory cytokines, such as IL-1β, IL-6 and TNF-α, as well as mTOR and IKKβ in the adipose tissues of the control and experimental rats in order to assess the ability of C. papaya to mitigate HFD-streptozotocin-incited inflammation and insulin resistance. The gene discussed is MTOR; the disease is Insulin resistance.