In smokers’ comparison, we found eight SNPs associated with COPD; six SNPs were associated with a higher risk of suffering COPD-S; rs11572191 in CYP2J2; rs8133 in MGST3; rs17497857 and rs4964059 in ARNTL2; and rs3901896 and rs8041826 in ARNT2, all with the minor allele. This evidence concerns the gene ARNT2 and chronic obstructive pulmonary disease.