MCOLN1 and Alzheimer disease: TRPML1 function is implicated in autophagic clearance of Aβ and tau in AD by being the primary activator of transcription factor EB (TFEB), the major regulator of lysosomal biogenesis and autophagy (Medina et al., 2015; Napolitano and Ballabio, 2016; Zhang et al., 2016).