PIKFYVE and Alzheimer disease: These Rab7-immunopositive vesicles included enlarged vacuoles within the soma, which were decorated with Rab7 immunoreactivity (Fig. 6A, zoom), as is typical for PIKfyve inhibition in many cell types (Bissig et al., 2017; Chen et al., 2017; Choy et al., 2018; Dong et al., 2010; Ikonomov et al., 2002, 2001; Jefferies et al., 2008; Kim et al., 2014; Martin et al., 2013; McCartney et al., 2014) and is similar to vesicles seen in the CA3 region of AD patients (Fig. 1C).