This includes regulation of mitochondrial Ca2+ dynamics (Calvo-Rodriguez et al., 2020; Jadiya et al., 2019) and ryanodine-receptor 2 (RyR2) Ca2+ release function (Thakore et al., 2020), which are known to be impaired in AD neurons (Chami and Checler, 2020; Kelliher et al., 1999; Lacampagne et al., 2017). Here, RYR2 is linked to Alzheimer disease.