LAMP1 and Alzheimer disease: A 3D reconstruction of LAMP1 immunoreactivity and positioning in a morphologically identifiable CA1 pyramidal neuron in AD compared to control pyramidal neurons is shown in Fig. 1B. Quantification, using CellProfiler, revealed that LAMP1 intensity was significantly increased in the perinuclear area of cells in the CA1 region in AD compared to in control cases (Fig. 1D,E).