MCOLN1 and Alzheimer disease: However, our results show alterations in PI dynamics in AD brain, selectively affecting two PI species with broad functions in EAL trafficking and function, namely PI(3,4,5)P3 and PI(4,5)P2 (Balla, 2013; Botelho, 2009; Di Paolo and De Camilli, 2006; Vanhaesebroeck et al., 2012), the latter of which operates as the endogenous antagonist of TRPML1.