However, western immunoblot analysis (Fig. 1I) and quantification (Fig. 1J) of temporal cortex membrane fractions prepared from AD and control brain showed only a non-significant trend towards an increase in LAMP1 levels in many AD samples compared with control levels, which is in line with previous literature (Bordi et al., 2016), and points rather to a shift in localization resulting in regional accumulation of lysosomes in the perinuclear region. Here, LAMP1 is linked to Alzheimer disease.