TPP1 and idiopathic pulmonary fibrosis: Overexpression of E3 ubiquitin-protein ligase FBW7 (F-box and WD40 repeat domain-containing 7, also termed FBXW7) inhibits the expression of telomere capping enzyme tripeptidyl peptidase 1 (TPP1), leading to shortening of telomeres, senescence of AT2 cells, and promotion of the occurrence and development of IPF [62].