IL18 and idiopathic pulmonary fibrosis: Cellular senescence is often accompanied by the generation of the senescence secretory phenotype (SASP), which in IPF senescent fibroblasts includes pro-inflammatory cytokines (e.g., TGF-, IL1β, IL-6, IL-18), chemokines (e.g., CXCL1), growth regulators (e.g., FGF, GM-CSF), matrix metalloproteinases (e.g., MMP-2, MMP-9) [86,100].