scRNA-seq revealed that genes complement C3a receptor 1 (C3ar1) and galectin-3, which play a key role in EC dynamic transition, were ubiquitously expressed by ECs in BLM-induced lung fibrosis, and ECM deposition was reduced and lung fibrosis was relieved after inhibition of this gene expression [171]. Here, C3AR1 is linked to pulmonary fibrosis.