At the same time, studies have found that α-ketoglutarate(α-KG), a metabolite of glutaminase, can promote the active expression of jumonji domain-containing protein-3 (JMJD3) in lung fibroblasts and combine with the apoptosis inhibitory proteins X-linked inhibitor of apoptosis (XIAP) and survivin to promote the anti-apoptotic function of IPF fibroblasts [108]. Here, XIAP is linked to idiopathic pulmonary fibrosis.