ANKLE1 and ovarian cancer: The human ortholog of LEM‐3 is known as ANKLE1.[14b] Recombinant ANKLE1 was shown to cleave a range of branched DNA species.[16]ANKLE1 was proposed to be the causal gene in the chr19p13.1 breast and ovarian cancer susceptibility locus,[17] suggesting that altered expression of ANKLE1 is involved in tumorigenesis.