Regarding history compatible with perennial house dust mite allergy, 816 (72.9%) out of 1120 patients had positive test results in SPT and sIgE, while 276 (24.6%) could only be detected by SPT versus 28 (2.5%) only by sIgE to the major allergens Der p1, Der p2 and/or Der p23 (p < 0.0001, Χ2 test, Figure 2B). The gene discussed is GHITM; the disease is allergic disease.